File(s) under permanent embargo
Bioprinting and biofabrication with peptide and protein biomaterials
journal contribution
posted on 2017-01-01, 00:00 authored by Mitchell Boyd-Moss, Kate Fox, Milan Brandt, David Nisbet, Richard WilliamsRichard WilliamsThe ability to fabricate artificial tissue constructs through the controlled organisation of cells, structures and signals within a biomimetic scaffold offers significant promise to the field of regenerative medicine, drug delivery and tissue engineering. Advances in additive manufacturing technologies have facilitated the printing of spatially defined cell-laden artificial tissue constructs capable of providing biomimetic spatiotemporal presentation of biological and physical cues to cells in a designed multicomponent structure. Despite significant progress in the field of bioprinting, a key challenge remains in developing and utilizing materials that can adequately recapitulate the complexities of the native extracellular matrix on a nanostructured, chemical level during the printing process. This gives rise to the need for suitable materials - particularly in establishing effective control over cell fate, tissue vascularization and innervation. Recently, significant interested has been invested into developing candidate materials using protein and peptide-derived biomaterials. The ability of these materials to form highly printable hydrogels which are reminiscent of the native ECM has seen significant use in a variety of regenative applications, including both organ bioprinting and non-organ bioprinting. Here, we discuss the emerging technologies for peptide-based bioprinting applications, highlighting bioink development and detailing bioprinter processors. Furthermore, this work presents application specific, peptide-based bioprinting approaches, and provides insight into current limitations and future perspectives of peptide-based bioprinting techniques.
History
Journal
Advances in experimental medicine and biologyVolume
1030Pagination
95 - 129Publisher
Springer VerlagLocation
United StatesPublisher DOI
ISSN
0065-2598eISSN
2214-8019Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2017, Springer International Publishing AGUsage metrics
Categories
No categories selectedKeywords
BiofabricationBioinkBioprintingPeptideProtein biomaterialsScience & TechnologyLife Sciences & BiomedicineBiologyMedicine, Research & ExperimentalLife Sciences & Biomedicine - Other TopicsResearch & Experimental MedicineMESENCHYMAL STEM-CELLSSILK FIBROINMECHANICAL-PROPERTIESHYDROGEL SCAFFOLDSVALVE CONDUITSCROSS-LINKINGPEG HYDROGELTISSUEBONE
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC