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Bioprinting and biofabrication with peptide and protein biomaterials

journal contribution
posted on 01.01.2017, 00:00 authored by Mitchell Boyd-Moss, Kate Fox, Milan Brandt, David Nisbet, Richard WilliamsRichard Williams
The ability to fabricate artificial tissue constructs through the controlled organisation of cells, structures and signals within a biomimetic scaffold offers significant promise to the field of regenerative medicine, drug delivery and tissue engineering. Advances in additive manufacturing technologies have facilitated the printing of spatially defined cell-laden artificial tissue constructs capable of providing biomimetic spatiotemporal presentation of biological and physical cues to cells in a designed multicomponent structure. Despite significant progress in the field of bioprinting, a key challenge remains in developing and utilizing materials that can adequately recapitulate the complexities of the native extracellular matrix on a nanostructured, chemical level during the printing process. This gives rise to the need for suitable materials - particularly in establishing effective control over cell fate, tissue vascularization and innervation. Recently, significant interested has been invested into developing candidate materials using protein and peptide-derived biomaterials. The ability of these materials to form highly printable hydrogels which are reminiscent of the native ECM has seen significant use in a variety of regenative applications, including both organ bioprinting and non-organ bioprinting. Here, we discuss the emerging technologies for peptide-based bioprinting applications, highlighting bioink development and detailing bioprinter processors. Furthermore, this work presents application specific, peptide-based bioprinting approaches, and provides insight into current limitations and future perspectives of peptide-based bioprinting techniques.

History

Journal

Advances in experimental medicine and biology

Volume

1030

Pagination

95 - 129

Publisher

Springer Verlag

Location

United States

ISSN

0065-2598

eISSN

2214-8019

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2017, Springer International Publishing AG