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Bipolar disorder and adiposity: A study using whole body dual energy X-ray absorptiometry scans

Version 2 2024-05-30, 15:38
Version 1 2014-10-28, 09:21
journal contribution
posted on 2024-05-30, 15:38 authored by Lana WilliamsLana Williams, Julie PascoJulie Pasco, Felice JackaFelice Jacka, MJ Henry, Seetal DoddSeetal Dodd, GC Nicholson, MA Kotowicz, Michael BerkMichael Berk
Williams LJ, Pasco JA, Jacka FN, Henry MJ, Dodd S, Nicholson GC, Kotowicz MA, Berk M. Bipolar disorder and adiposity: a study using whole body dual energy X-ray absorptiometry scans.Objective:Previous research has demonstrated a relationship between adiposity and bipolar disorder, although data are derived predominantly from patient samples and use indirect methods of assessing adiposity. This study investigated the association between bipolar disorder and several indices of adiposity, including body fat mass as measured by dual energy X-ray absorptiometry (DXA), in a community-based sample.Methods:In this study, 21 women with bipolar disorder and 523 healthy controls were drawn from an age-stratified, random, community-based sample of women (20–93 years) participating in the Geelong Osteoporosis Study. Bipolar disorder was diagnosed utilising a semi-structured clinical interview. Anthropometric measurements (weight, height, waist and hip circumference) were taken and fat mass was determined from whole body DXA scans (Lunar DPX-L).ResultsThose with bipolar disorder tended to have greater adiposity. Age-adjusted mean (95% CI) values for bipolar versus controls according to adiposity indices were weight 75.6 (68.9–82.3) versus 72.6 (71.3–74.0) kg, waist circumference 89.8 (84.1–95.6) versus 87.3 (86.1–88.5) cm, waist:hip ratio 0.85 (0.82–0.87) versus 0.84 (0.83–0.84), body mass index 27.6 (25.1–30.1) versus 27.5 (27.0–28.0) kg/m2, fat mass 31.4 (26.5–36.3) versus 28.6 (27.5–29.5) kg and %body fat 40.4 (36.9–43.9) versus 38.0 (37.3–38.7)%; allp> 0.05. Further adjustment for height, smoking, alcohol, psychotropic medication, energy intake or physical activity did not influence these patterns.ConclusionAlthough a pattern suggestive of greater adiposity among those with bipolar disorder was observed, no significant differences were detected. We cannot exclude the possibility of a type II error. Further research with a larger sample may produce more conclusive results.

History

Journal

Acta Neuropsychiatrica

Volume

23

Pagination

219-223

Location

England

ISSN

0924-2708

eISSN

1601-5215

Language

English

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2011, John Wiley & Sons

Issue

5

Publisher

WILEY-BLACKWELL