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Blocking HIV-1 transmission in the female reproductive tract: from microbicide development to exploring local antiviral responses

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journal contribution
posted on 2015-10-09, 00:00 authored by Sahar Eid, N E Mangan, P J Hertzog, Johnson Mak
The majority of new HIV-1 infections are transmitted sexually by penetrating the mucosal barrier to infect target cells. The development of microbicides to restrain heterosexual HIV-1 transmission in the past two decades has proven to be a challenging endeavor. Therefore, better understanding of the tissue environment in the female reproductive tract may assist in the development of the next generation of microbicides to prevent HIV-1 transmission. In this review, we highlight the important factors involved in the heterosexual transmission of HIV-1, provide an update on microbicides' clinical trials, and discuss how different delivery platforms and local immunity may empower the development of next generation of microbicide to block HIV-1 transmission in the female reproductive tract.

History

Journal

Clinical and translational immunology

Volume

4

Issue

10

Article number

e43

Pagination

1 - 9

Publisher

Nature Publishing Group

Location

London, Eng.

eISSN

2050-0068

Language

eng

Publication classification

C Journal article; C1 Refereed article in a scholarly journal

Copyright notice

2015, Australasian Society for Immunology