belavy-bonestructure-2011.pdf (2.26 MB)
Bone structure and density via HR-pQCT in 60d bed-rest, 2-years recovery with and without countermeasures
journal contribution
posted on 2011-09-01, 00:00 authored by Daniel Belavy, G Beller, Z Ritter, D FelsenbergWe examined the effects of bed-rest, recovery and exercise countermeasures on bone density and structure at the distal tibia and radius as measured via high-resolution peripheral computed tomography. 24 subjects underwent 60-days of head-down tilt bed-rest and performed either resistive vibration exercise (RVE; n = 7), resistive exercise only (RE; n = 8) or no exercise (n = 9; 2nd Berlin BedRest Study; BBR2-2). Measurements were performed regularly during and up to 2-years after 60d bed-rest. At the distal tibia marked reductions in cortical area, cortical thickness and bone density but increases in periosteal perimeter and trabecular area were seen (p all<0.001). Recovery of most parameters occurred within 180d after bed-rest. At the distal radius, persistent increases in cortical area, cortical thickness, cortical density and total density and decreases in trabecular area were seen (p all ≤ 0.005). A significant effect of RVE (p = 0.003), but not RE, was seen on cortical area at the distal tibia, with few effects of the countermeasures observed on the remaining parameters. The current study represents the first implementation of high-resolution peripheral computed tomography in bed-rest in male subjects and helps to understand the patterns of bone remodeling due to bed-rest and recovery.
History
Journal
Journal of musculoskeletal and neuronal interactionsVolume
11Issue
3Pagination
215 - 226Publisher
International Society of Musculoskeletal and Neuronal InteractionsLocation
Kifissia, GreeceISSN
1108-7161Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2011, International Society of Musculoskeletal and Neuronal InteractionsUsage metrics
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AdultBed RestBone ResorptionExercise TherapyHumansMaleRadiusRecovery of FunctionSpace FlightTibiaTomography, X-Ray ComputedTreatment OutcomeYoung AdultScience & TechnologyLife Sciences & BiomedicineNeurosciencesPhysiologyNeurosciences & Neurologymicro-CT3D-pQCTSpaceflightImmobilizationTrainingTRABECULAR BONEMECHANICAL-PROPERTIESMUSCLE ATROPHYSTRENGTHWOMENALENDRONATE
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