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Boosting airway T-regulatory cells by gastrointestinal stimulation as a strategy for asthma control

journal contribution
posted on 2011-01-01, 00:00 authored by D H Strickland, S Judd, J A Thomas, A N Larcombe, Peter Sly, P G Holt
The hallmark of atopic asthma is transient airways hyperresponsiveness (AHR) preceded by aeroallergen-induced Th-cell activation. This is preceded by upregulation of CD86 on resident airway dendritic cells (DCs) that normally lack competence in T-cell triggering. Moreover, AHR duration is controlled via T-regulatory (Treg) cells, which can attenuate CD86 upregulation on DC. We show that airway mucosal Treg/DC interaction represents an accessible therapeutic target for asthma control. Notably, baseline airway Treg activity in sensitized rats can be boosted by microbe-derived stimulation of the gut, resulting in enhanced capacity to control CD86 expression on airway DC triggered by aeroallergen and accelerated resolution of AHR. © 2011 Society for Mucosal Immunology.

History

Journal

Mucosal Immunology

Volume

4

Issue

1

Pagination

43 - 52

ISSN

1933-0219