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Brain volumetric correlates of inhibition and cognitive flexibility 16 years following childhood traumatic brain injury
journal contribution
posted on 2018-04-01, 00:00 authored by Kelleynne Yu, Marc L Seal, Jonathan Reyes, Celia Godfrey, Vicki Anderson, Chris Adamson, Nicholas RyanNicholas Ryan, Stephen J C Hearps, Cathy CatroppaExecutive functions (EFs), such as inhibition and cognitive flexibility, are essential for everyday functioning, including regulation of socially appropriate emotional responses. These skills develop during childhood and continue maturing into early adulthood. The current study aimed to investigate the very long-term impact of childhood traumatic brain injury (TBI) on inhibition and cognitive flexibility, and to examine whether global white matter is associated with these abilities. Twenty-eight young adult survivors of childhood TBI (mean age at 16-year follow-up = 21.67 years, SD = 2.70) and 16 typically developing controls (TDCs), group-matched for age, sex, and socioeconomic status, completed tests of inhibition and cognitive flexibility and underwent structural MRI. Survivors of childhood TBI did not significantly differ from TDCs on EF or white matter volume. However, the relationship between EF and white matter volume differed between survivors of TBI and TDCs. Survivors of TBI did not mimic the brain behavior relationship that characterized EF in TDCs. The inverse brain behavior relationship, exhibited by childhood TBI survivors, suggests disruptions in the whole brain underpinning EF following childhood TBI.
History
Journal
Journal of neuroscience researchVolume
96Issue
4Pagination
642 - 651Publisher
John Wiley & SonsLocation
Chichester, Eng.Publisher DOI
eISSN
1097-4547Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2017, Wiley Periodicals, Inc.Usage metrics
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traumatic brain injurycognitive functionwhite matterexecutive functioninhibitioncognitive flexibilitychildhoodScience & TechnologyLife Sciences & BiomedicineNeurosciencesNeurosciences & NeurologyATTENTION-DEFICIT\/HYPERACTIVITY DISORDERWHITE-MATTERLONGITUDINAL CHANGESPRESCHOOL-CHILDRENFRONTAL LOBESADOLESCENCESEVERITYIMPACTMILD
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