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Can cancer therapy be achieved by bridging apoptosis and autophagy: A method based on microRNA-dependent gene therapy and phytochemical targets

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journal contribution
posted on 2015-01-01, 00:00 authored by S Vijayarathna, S Gothai, S L Jothy, Y Chen, Jagat Kanwar, S Sasidharan
A failure of a cell to self destruct has long been associated with cancer progression and development. The fact that tumour cells may not instigate cell arrest or activate cell death mechanisms upon cancer drug delivery is a major concern. Autophagy is a mechanism whereby cell material can be engulfed and digested while apoptosis is a self-killing mechanism, both capable of hindering multiplication after cell injury. In particular situations, autophagy and apoptosis seem to co-exist simultaneously or interdependently with the aid of mutual proteins. This review covers roles of microRNAs and chemopreventive agents and makes an attempt at outlining possible partnerships in maximizing cancer cell death with minimal normal cell damage.

History

Journal

Asian pacific journal of cancer prevention

Volume

16

Issue

17

Pagination

7435 - 7439

Publisher

Asian Pacific Education Press

Location

Bangkok, Asia

ISSN

1513-7368

Language

eng

Publication classification

C Journal article; C1 Refereed article in a scholarly journal

Copyright notice

2015, Asian Pacific Education Press

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