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Can energetic capacity help explain why physical activity reduces cancer risk?
journal contribution
posted on 2020-10-01, 00:00 authored by Peter BiroPeter Biro, F Thomas, Beata UjvariBeata Ujvari, Christa BeckmannChrista BeckmannIncreased physical activity reduces cancer risk in humans, but why this whole-organism attribute reduces cancer remains unclear. Active individuals tend to have high capacity to generate energy on a sustained basis, which in turn can permit greater immune responses crucial for fighting emerging neoplasia. Thus, we suggest energetic capacity as a potential mechanism to explain the activity–cancer link, given that humans are intrinsically (not externally) energy limited. Human and rodent studies show that individuals with high energetic capacity mount greater immune responses and have lower cancer incidence; these trends persist after controlling for actual physical activity, supporting a direct role of energetic capacity. If true, exercise efforts might best target those that increase one's energetic capacity, which may be both individual and exercise specific.
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Journal
Trends in cancerVolume
6Issue
10Pagination
829 - 837Publisher
ElsevierLocation
Amsterdam, The NetherlandsPublisher DOI
ISSN
2405-8033eISSN
2405-8033Language
engPublication classification
C Journal article; C1 Refereed article in a scholarly journalUsage metrics
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