Can gut microbiota composition predict response to dietary treatments?
journal contributionposted on 2019-05-01, 00:00 authored by J R Biesiekierski, J Jalanka, Heidi StaudacherHeidi Staudacher
Dietary intervention is a challenge in clinical practice because of inter-individual variability in clinical response. Gut microbiota is mechanistically relevant for a number of disease states and consequently has been incorporated as a key variable in personalised nutrition models within the research context. This paper aims to review the evidence related to the predictive capacity of baseline microbiota for clinical response to dietary intervention in two specific health conditions, namely, obesity and irritable bowel syndrome (IBS). Clinical trials and larger predictive modelling studies were identified and critically evaluated. The findings reveal inconsistent evidence to support baseline microbiota as an accurate predictor of weight loss or glycaemic response in obesity, or as a predictor of symptom improvement in irritable bowel syndrome, in dietary intervention trials. Despite advancement in quantification methodologies, research in this area remains challenging and larger scale studies are needed until personalised nutrition is realistically achievable and can be translated to clinical practice.
Pagination1 - 15
Link to full text
Publication classificationC1 Refereed article in a scholarly journal
Copyright notice2019, the authors
Read the peer-reviewed publication
personalised nutritionmicrobiotadietary interventionobesityirritable bowel syndromegastrointestinal symptomsScience & TechnologyLife Sciences & BiomedicineNutrition & DieteticsIRRITABLE-BOWEL-SYNDROMELOW FODMAP DIETBODY-MASS INDEXFECAL MICROBIOTAWEIGHT-LOSSGASTROINTESTINAL MICROBIOTAINTESTINAL MICROBIOTAMETABOLIC SYNDROMECLINICAL-RESPONSEREDUCES SYMPTOMS