Cancer stem cell targeted therapy: progress amid controversies
journal contributionposted on 2015-12-29, 00:00 authored by Tao Wang, Sarah ShigdarSarah Shigdar, M P Gantier,, Y Hou,, L Wang,, Y Li,, H A Shamaileh,, Wang Yin, S F Zhou,, X Zhao,, Wei DuanWei Duan
Although cancer stem cells have been well characterized in numerous malignancies, the fundamental characteristics of this group of cells, however, have been challenged by some recent observations: cancer stem cells may not necessary to be rare within tumors; cancer stem cells and non-cancer stem cells may undergo reversible phenotypic changes; and the cancer stem cells phenotype can vary substantially between patients. Here the current status and progresses of cancer stem cells theory is illustrated and via providing a panoramic view of cancer therapy, we addressed the recent controversies regarding the feasibility of cancer stem cells targeted anti-cancer therapy.
Pagination44191 - 44206
Publication classificationC Journal article; C1 Refereed article in a scholarly journal
Copyright notice2015, The Authors
CategoriesNo categories selected
anti-cancer treatmentcancercancer stem cellcancer stem cell markercancer stem cell modelScience & TechnologyLife Sciences & BiomedicineOncologyCell BiologyACUTE MYELOID-LEUKEMIAACTIVATION PREDICTS RESPONSEINITIATING CELLSTUMOR-GROWTHPHENOTYPIC HETEROGENEITYIMMUNODEFICIENT MICESECRETASE INHIBITORSREPOPULATING CELLSPERIPHERAL-BLOODIMMUNE-SYSTEM