Cancer stem cells: a contentious hypothesis now moving forward
Version 2 2024-06-05, 09:50
Version 1 2014-11-12, 09:24
journal contribution
posted on 2024-06-05, 09:50 authored by ML O'Connor, D Xiang, Sarah ShigdarSarah Shigdar, Joanna MacdonaldJoanna Macdonald, Y Li, T Wang, C Pu, Z Wang, L Qiao, Wei DuanWei DuanCancer stem cells are a progressive concept to account for the cell biological nature of cancer. Despite the controversies regarding the cancer stem cell model, it has the potential to provide a foundation for new innovative treatment targeting the roots of cancer. The last two years have witnessed exceptional progress in cancer stem cell research, in particular on solid tumours, which holds promise for improved treatment outcomes. Here, we review recent advances in cancer stem cell research, discuss challenges in the field and explore future strategies and opportunities in cancer stem cell studies to overcome resistance to chemotherapy.
History
Journal
Cancer lettersVolume
344Pagination
180-187Location
Shannon, IrelandPublisher DOI
ISSN
0304-3835eISSN
1872-7980Language
engNotes
1872-7980 O'Connor, Michael L Xiang, Dongxi Shigdar, Sarah Macdonald, Joanna Li, Yong Wang, Tao Pu, Chunwen Wang, Zhidong Qiao, Liang Duan, Wei Journal Article Research Support, Non-U.S. Gov't Review Ireland Cancer Lett. 2014 Mar 28;344(2):180-7. doi: 10.1016/j.canlet.2013.11.012. Epub 2013 Dec 11. Cancer stem cells are a progressive concept to account for the cell biological nature of cancer. Despite the controversies regarding the cancer stem cell model, it has the potential to provide a foundation for new innovative treatment targeting the roots of cancer. The last two years have witnessed exceptional progress in cancer stem cell research, in particular on solid tumours, which holds promise for improved treatment outcomes. Here, we review recent advances in cancer stem cell research, discuss challenges in the field and explore future strategies and opportunities in cancer stem cell studies to overcome resistance to chemotherapy.Publication classification
C Journal article, C1 Refereed article in a scholarly journalCopyright notice
2014, Elsevier IrelandIssue
2Publisher
Elsevier IrelandUsage metrics
Keywords
AptamersCancer stem cellsChemoresistanceClonal evolutionStemnessAnimalsDrug Resistance, NeoplasmHumansNeoplasmsNeoplastic Stem CellsAnimals Drug Resistance, Neoplasm Humans Neoplasms/drug therapy/*pathology Neoplastic Stem Cells/*pathology Aptamers Cancer stem cells Chemoresistance Clonal evolution Stemness111201 Cancer Cell Biology920102 Cancer and Related DisordersSchool of MedicineMolecular and Medical Research Group
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