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Candida glabrata prosthetic valve endocarditis treated successfully with fluconazole plus caspofungin without surgery: a case report and literature review.
journal contribution
posted on 2005-11-01, 00:00 authored by D C B Lye, Andrew HughesAndrew Hughes, Daniel O'Brien, Eugene AthanEugene AthanReported here is the case of a 72-year-old man who was diagnosed with Candida glabrata prosthetic mitral valve endocarditis and treated successfully with fluconazole plus caspofungin after he refused and was determined unfit for surgery. Initial treatment with intravenous amphotericin B resulted in acute renal impairment. Despite 8 days of intravenous fluconazole therapy, he remained fungemic. Caspofungin was added to the treatment regimen with subsequent sterilisation of blood culture. The patient was treated for 34 days with caspofungin and 41 days with fluconazole. He continued oral fluconazole after hospital discharge and remained well at follow-up 11 months later. The role of fluconazole and caspofungin in the treatment of Candida endocarditis is discussed.
History
Journal
European Journal of Clinical Microbiology and Infectious DiseasesVolume
24Issue
11Pagination
753 - 755Publisher
Springer VerlagLocation
GermanyPublisher DOI
ISSN
0934-9723Language
engPublication classification
C1.1 Refereed article in a scholarly journalUsage metrics
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No categories selectedKeywords
Acute Kidney InjuryAgedAmphotericin BAntifungal AgentsCandida glabrataCandidiasisDrug Therapy, CombinationEchinocandinsEndocarditisFluconazoleHeart Valve ProsthesisHumansLipopeptidesMaleMitral ValvePeptides, CyclicProsthesis-Related InfectionsScience & TechnologyLife Sciences & BiomedicineInfectious DiseasesMicrobiologyAMPHOTERICIN-BCOMBINATION THERAPYFUNGAL ENDOCARDITISSUSCEPTIBILITYBIOFILMS
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