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Candida glabrata prosthetic valve endocarditis treated successfully with fluconazole plus caspofungin without surgery: a case report and literature review.

journal contribution
posted on 2005-11-01, 00:00 authored by D C B Lye, Andrew HughesAndrew Hughes, Daniel O'Brien, Eugene AthanEugene Athan
Reported here is the case of a 72-year-old man who was diagnosed with Candida glabrata prosthetic mitral valve endocarditis and treated successfully with fluconazole plus caspofungin after he refused and was determined unfit for surgery. Initial treatment with intravenous amphotericin B resulted in acute renal impairment. Despite 8 days of intravenous fluconazole therapy, he remained fungemic. Caspofungin was added to the treatment regimen with subsequent sterilisation of blood culture. The patient was treated for 34 days with caspofungin and 41 days with fluconazole. He continued oral fluconazole after hospital discharge and remained well at follow-up 11 months later. The role of fluconazole and caspofungin in the treatment of Candida endocarditis is discussed.

History

Journal

European Journal of Clinical Microbiology and Infectious Diseases

Volume

24

Issue

11

Pagination

753 - 755

Publisher

Springer Verlag

Location

Germany

ISSN

0934-9723

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal