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Cardiovascular and renal disease in the adolescent guinea pig after chronic placental insufficiency

journal contribution
posted on 2004-09-01, 00:00 authored by Todd A Briscoe, Alexandra E Rehn, Sandra Dieni, Jhodie R Duncan, Mary E Wlodek, Julie OwensJulie Owens, Sandra M Rees
OBJECTIVE: The aim of this study was to determine the long-term effects of chronic placental insufficiency on the metabolic state and organ structure in the fetal and adolescent guinea pig. STUDY DESIGN: The maternal uterine artery was ligated at day 28-30 to reduce placental function and restrict fetal growth. Whole body and tissue weights and plasma metabolites were determined at 60 days of gestation and 8 weeks of age; tissue structure was determined at the latter age in restricted and control offspring. RESULTS: Fetal growth restriction increased fibrosis in the heart and kidneys (P < .05), increased aortic wall thickening (P < .01), reduced the number of glomeruli in the kidneys (P < .05), and increased the plasma urea and chloride in adolescent offspring. CONCLUSION: This study demonstrates that diseases in the heart, aorta, and kidneys that result from an adverse prenatal environment are evident at adolescence and may contribute to subsequent adult disease.

History

Journal

American journal of obstetrics and gynecology

Volume

191

Issue

3

Pagination

847 - 855

Publisher

Elsevier

Location

Amsterdam, The Netherlands

ISSN

0002-9378

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

2004, Elsevier Inc.