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Case report of interstitial nephritis induced by bevacizumab therapy for glioblastoma multiforme

journal contribution
posted on 2013-12-01, 00:00 authored by A J Lomax, P A Hill, David Ashley
Glioblastoma multiforme is an aggressive malignant brain tumor. The monoclonal antibody, bevacizumab, is active in recurrent disease via inhibition of angiogenesis. Proteinuria and renal thrombotic microangiopathy are known complications. We report a case of a patient developing acute renal failure with biopsy-proven interstitial nephritis while receiving bevacizumab for recurrent disease. The patient was otherwise well with a history of controlled hypertension. Renal function improved with discontinuation of bevacizumab and the administration of corticosteroid therapy.

History

Journal

Journal of oncology pharmacy practice

Volume

19

Issue

4

Pagination

365 - 368

Publisher

Sage Publications

Location

London, Eng.

ISSN

1078-1552

eISSN

1477-092X

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

2012, The Author(s)