File(s) under permanent embargo
Cavum septum pellucidum in pediatric traumatic brain injury
journal contribution
posted on 2013-09-30, 00:00 authored by Tim SilkTim Silk, Richard Beare, Louise Crossley, Kirrily Rogers, Louise Emsell, Cathy Catroppa, Miriam Beauchamp, Vicki AndersonThe cavum septum pellucidum (CSP) is a fluid-filled cavity in the thin midline structure of the septum pellucidum. The CSP has been linked to several neurodevelopmental disorders, but it also occurs as a result of head injury. The aims were to assess the presence and characterization of the CSP in youth with traumatic brain injury (TBI), to assess whether injury severity or IQ measures were related to CSP size, and to examine brain morphometry changes associated with the CSP size. Ninety-eight survivors of TBI and 34 control children underwent magnetic resonance imaging (MRI). Numerous methods were used to define the presence and characterization of the CSP including length, classification of abnormally large CSP, rating of the CSP, and volume. There was no difference in presence of CSP between TBI patients and controls; however, there was larger and more severely graded CSP in the patient group. Size of the CSP correlated positively with injury severity, and regions that correlated most significantly with CSP size were the right entorhinal cortex and bilateral hippocampus. Characterizing the CSP and related brain changes may provide important information concerning disturbances seen after a TBI.
History
Journal
Psychiatry research: neuroimagingVolume
213Issue
3Pagination
186 - 192Publisher
ElsevierLocation
Amsterdam, The NetherlandsPublisher DOI
eISSN
1872-7123Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2013, Elsevier Ireland Ltd.Usage metrics
Categories
No categories selectedKeywords
Cavum septum pellucidumMagnetic resonance imaging (MRI)PediatricTraumatic brain injuryAdolescentBrain InjuriesCase-Control StudiesChildChild, PreschoolDevelopmental DisabilitiesFemaleGlasgow Coma ScaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMalePediatricsSeptum PellucidumTomography, X-Ray ComputedScience & TechnologyLife Sciences & BiomedicineClinical NeurologyNeuroimagingPsychiatryNeurosciences & NeurologyULTRA-HIGH-RISKBIPOLAR DISORDERSCHIZOPHRENIAMRIPREVALENCEMODERATEATROPHYSEGMENTATIONHIPPOCAMPUSCHILDREN
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC