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Changes in MRI head motion across development: typical development and ADHD

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journal contribution
posted on 2025-04-16, 06:05 authored by Phoebe Thomson, Vanessa Loosley, Emily FriedelEmily Friedel, Tim SilkTim Silk
AbstractHead motion is a major confounding variable for magnetic resonance imaging (MRI) analysis, and is commonly seen in individuals with neurodevelopmental disorders such as attention deficit hyperactivity disorder (ADHD). This study investigated the trajectory of change in head motion in typically developing children and children with ADHD, and examined possible altered trajectories in head motion between children with remitted and persistent ADHD. 105 children with ADHD and 84 controls completed diffusion and resting-state functional MRI scans at up to three waves over ages 9–14 years. In-scanner head motion was calculated using framewise displacement, and longitudinal trajectories analyzed using generalized additive mixed modelling. Results revealed a significant age effect on framewise displacement where head motion decreased as age increased during both diffusion (p < .001) and resting-state functional MRI (p < .001). A significant effect of group was also observed; children with ADHD displayed greater framewise displacement than controls over the age range (diffusion MRI p = .036, functional MRI p = .004). Further analyses revealed continued elevation in head motion in children in remission from ADHD (diffusion MRI p = .020, functional MRI p = .011) compared to controls. Rates of change in head motion did not significantly differ between diagnostic groups. Findings indicate a critical link between in-scanner head motion and developmental age within children regardless of ADHD diagnosis, important to consider in studies of neurodevelopment. Findings also suggest change in head motion with age does not differ between individuals with remitted and persistent ADHD, adding further evidence that behavioral manifestations of ADHD may continue despite clinical remission.

History

Journal

Brain Imaging and Behavior

Volume

18

Pagination

1144-1152

Location

Berlin, Germany

Open access

  • Yes

ISSN

1931-7557

eISSN

1931-7565

Language

eng

Notes

In press

Publication classification

C1 Refereed article in a scholarly journal

Publisher

Springer

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