peeters-changesinabdominal-2008.pdf (104.21 kB)
Changes in abdominal obesity and age-related macular degeneration: the atherosclerosis risk in communities study
journal contribution
posted on 2008-11-01, 00:00 authored by Anna PeetersAnna Peeters, D J Magliano, J Stevens, B B Duncan, R Klein, T Y WongOBJECTIVE: To examine the association between changes in waist-hip ratio (WHR), a measure of abdominal obesity, and age-related macular degeneration (AMD). METHODS: A total of 12 515 persons from a population-based cohort study, aged 45 to 64 years in 1987 to 1989, were followed up over 6 years. The percentage change in WHR during follow-up was ranked into sex-specific deciles; an increase in WHR was defined as the top 10% of change and a decrease in WHR as the bottom 10%. The association of increased or decreased WHR and presence of AMD at follow-up was determined using logistic regression adjusting for potential confounders. RESULTS: The average change in WHR was an increase of 2%, ranging from a decrease of 44% to an increase of 102%. A decrease in WHR of 3% or more was associated with 29% lower odds of any AMD (odds ratio = 0.71; 95% confidence interval, 0.52-0.97). This effect was most pronounced among obese participants at baseline, where a decrease in WHR was associated with 59% lower odds of AMD (odds ratio = 0.41; 95% confidence interval, 0.20-0.82). CONCLUSIONS: Middle-aged persons who had a 3% or greater reduction in WHR over time were less likely to have AMD, particularly among those who were initially obese.
History
Journal
Archives of ophthalmologyVolume
126Issue
11Pagination
1554 - 1560Publisher
American Medical AssociationLocation
Chicago, Ill.Publisher DOI
Link to full text
ISSN
1538-3601eISSN
1538-3601Language
engPublication classification
C Journal article; C1.1 Refereed article in a scholarly journalCopyright notice
2008, American Medical AssociationUsage metrics
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No categories selectedKeywords
Abdominal FatAtherosclerosisBody Mass IndexBody WeightFemaleFollow-Up StudiesHumansMacular DegenerationMaleMiddle AgedObesityOdds RatioRisk FactorsUnited StatesWaist-Hip RatioScience & TechnologyLife Sciences & BiomedicineOphthalmologyBODY-MASS INDEXBEAVER DAM EYECARDIOVASCULAR-DISEASEPHYSICAL-ACTIVITYWEIGHT CHANGEMACULOPATHYMENHYPERTENSIONPATHOGENESIS
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