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Changes in attitudes to awareness of hypoglycaemia during a hypoglycaemia awareness restoration programme are associated with avoidance of further severe hypoglycaemia episodes within 24 months: the A2A in HypoCOMPaSS study
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posted on 2023-02-16, 03:38 authored by E Sepúlveda, P Jacob, R Poínhos, D Carvalho, SG Vicente, EL Smith, JAM Shaw, Jane SpeightJane Speight, P Choudhary, N de Zoysa, SA AmielAims/hypothesis: The aims of this study were to assess cognitions relating to hypoglycaemia in adults with type 1 diabetes and impaired awareness of hypoglycaemia before and after the multimodal HypoCOMPaSS intervention, and to determine cognitive predictors of incomplete response (one or more severe hypoglycaemic episodes over 24 months). Methods: This analysis included 91 adults with type 1 diabetes and impaired awareness of hypoglycaemia who completed the Attitudes to Awareness of Hypoglycaemia (A2A) questionnaire before, 24 weeks and 24 months after the intervention, which comprised a short psycho-educational programme with optimisation of insulin therapy and glucose monitoring. Results: The age and diabetes duration of the participants were 48±12 and 29±12 years, respectively (mean±SD). At baseline, 91% reported one or more severe hypoglycaemic episodes over the preceding 12 months; this decreased to <20% at 24 weeks and after 24 months (p=0.001). The attitudinal barrier ‘hyperglycaemia avoidance prioritised’ (η2p=0.250, p=0.001) decreased from baseline to 24 weeks, and this decrease was maintained at 24 months (mean±SD=5.3±0.3 vs 4.3±0.3 vs 4.0±0.3). The decrease in ‘asymptomatic hypoglycaemia normalised’ from baseline (η2p=0.113, p=0.045) was significant at 24 weeks (1.5±0.3 vs 0.8±0.2). Predictors of incomplete hypoglycaemia response (one or more further episodes of severe hypoglycaemia) were higher baseline rates of severe hypoglycaemia, higher baseline scores for ‘asymptomatic hypoglycaemia normalised’, reduced change in ‘asymptomatic hypoglycaemia normalised’ scores at 24 weeks, and lower baseline ‘hypoglycaemia concern minimised’ scores (all p<0.05). Conclusions/interpretation: Participation in the HypoCOMPaSS RCT was associated with improvements in hypoglycaemia-associated cognitions, with ‘hyperglycaemia avoidance prioritised’ most prevalent. Incomplete prevention of subsequent severe hypoglycaemia episodes was associated with persistence of the cognition ‘asymptomatic hypoglycaemia normalised’. Understanding and addressing cognitive barriers to hypoglycaemia avoidance is important in individuals prone to severe hypoglycaemia episodes. Clinical trials registration: www.isrctn.org: ISRCTN52164803 and https://eudract.ema.europa.eu: EudraCT2009-015396-27. Graphical abstract: [Figure not available: see fulltext.].
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Journal
DiabetologiaLocation
GermanyPublisher DOI
ISSN
0012-186XeISSN
1432-0428Language
EnglishPublication classification
C1 Refereed article in a scholarly journalPublisher
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Keywords
Science & TechnologyLife Sciences & BiomedicineEndocrinology & MetabolismHypoglycaemiaImpaired awareness of hypoglycaemiaType 1 diabetesREQUIRING EMERGENCY TREATMENTPSYCHOEDUCATIONAL PROGRAMSTRUCTURED EDUCATIONIMPAIRED AWARENESSINSULIN PUMPDAFNE-HARTADULTSUNAWARENESSCAREMULTICENTERHypoCOMPaSS Study GroupDiabetesClinical ResearchMetabolic and endocrinePublic Health and Health Services not elsewhere classifiedClinical Sciences not elsewhere classifiedPaediatrics and Reproductive Medicine not elsewhere classified
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