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Changes in the NS Gene of Neurovirulent Strains of Influenza Affect Splicing.

Version 2 2024-06-03, 21:28
Version 1 2017-05-16, 15:52
journal contribution
posted on 2024-06-03, 21:28 authored by Alister WardAlister Ward, AA Azad, JL McKimm-Breschkin
The nonstructural (NS) gene has been identified as an accessory factor in determining neurovirulence for influenza A virus. The nucleotide sequence of the NS gene of the neurovirulent variant A/NWS/33 was determined and compared with its parent, A/WS/33. Alterations in the mRNA structure of the gene were observed that serve to mask the 3' splice site. Changes in this region were shown to correlate with reduced splicing of the NS gene in neurovirulent strains.

History

Journal

Virus Genes

Volume

10

Pagination

91-94

Location

United States

ISSN

0920-8569

Language

eng

Publication classification

CN.1 Other journal article

Issue

1

Publisher

Springer New York LLC

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