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Chasing the personalized medicine dream through biomarker validation in colorectal cancer.

journal contribution
posted on 2017-01-01, 00:00 authored by Harshali Anant Patil, S G Saxena, Colin BarrowColin Barrow, Jagat Kanwar, Arnab KapatArnab Kapat, Rupinder Kanwar
Colorectal cancer (CRC) is a major health burden worldwide. The optimal approach to the diagnosis, management, and treatment of CRC involves multidisciplinary and integrated management practices. The field is rapidly changing because of recent advancements in delineating the molecular basis of tumorigenesis, introduction of targeted therapy, varied patient response to mainstay chemotherapeutics, biological drugs, and the effective combination regimes being used for treatment. Recent meta-analysis studies, which tend to establish few clinically useful predictor biomarkers, identify inconsistent results and limitations of the trials. Therefore, molecular pathological epidemiology discipline initiatives are promising. Here, we provide an overview of the potential of biomarker validation for personalized medicine by focusing largely on metastatic (m)CRC. We also highlight new candidate predictive and prognostic biomarkers.

History

Journal

Drug discovery today

Volume

22

Issue

1

Pagination

111 - 119

Publisher

Elsevier

Location

Amsterdam, The Netherlands

ISSN

1878-5832

eISSN

1878-5832

Language

eng

Publication classification

C Journal article; C1 Refereed article in a scholarly journal

Copyright notice

2016, Elsevier