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Chemiluminescence detection of cannabinoids and related compounds with acidic potassium permanganate.

Version 2 2024-06-04, 05:43
Version 1 2022-12-01, 00:13
journal contribution
posted on 2024-06-04, 05:43 authored by BJ Holland, Paul FrancisPaul Francis, B Li, T Tsuzuki, Jacqui AdcockJacqui Adcock, NW Barnett, Xavier ConlanXavier Conlan
This is the first report of chemiluminescence from the reaction of cannabinoids with acidic potassium permanganate, which we have applied to the high performance liquid chromatography (HPLC) determination of cannabidiol (CBD) in industrial-grade hemp. The intensities of the light-producing reactions with two commercially available cannabinoid standards were compared to that of seven model phenolic analytes. Resorcinol, representing the parent phenolic moiety of the cannabinoid class, was shown to react with the permanganate reagents in a manner more similar to phenol than to its hydroxyphenol positional isomers, pyrocatechol and hydroquinone. Alkyl substituents on the phenolic ring, however, have a considerable impact on emission intensity that is dependent upon the position of the groups and the composition of the permanganate reagent. This analytical approach has potential for the determination of other cannabinoids including Δ(9) -tetrahydrocannabinol in drug-grade cannabis. Copyright © 2012 John Wiley & Sons, Ltd.

History

Journal

Drug testing and analysis

Volume

4

Pagination

675-679

eISSN

1942-7611

Publication classification

C Journal article, C1.1 Refereed article in a scholarly journal

Issue

7-8

Publisher

John Wiley & Sons