Chimeric nucleolin aptamer with survivin DNAzyme for cancer cell targeted delivery

Subramanian, N; Kanwar, JR; Akilandeswari, B; Kanwar, RK; Khetan, V; Krishnakumar, S

Chimeric nucleolin aptamer with survivin DNAzyme for cancer cell targeted delivery

journal contribution

posted on 2024-06-13, 15:38 authored by N Subramanian, JR Kanwar, B Akilandeswari, RK Kanwar, V Khetan, S Krishnakumar

A chimeric aptamer-DNAzyme conjugate was generated for the first time using a nucleolin aptamer (NCL-APT) and survivin Dz (Sur_Dz) and exhibited the targeted killing of cancer cells. This proof of concept of using an aptamer for the delivery of DNAzyme can be applied to other cancer types to target survivin in cancer cells in a specific manner.

History

Journal

Chemical communications

Volume

51

Pagination

6940-6943

Location

Cambridge, Eng.

ISSN

1364-548X

Language

eng

Author URL

http://www.ncbi.nlm.nih.gov/pubmed/25797393

Publication classification

C Journal article, C1 Refereed article in a scholarly journal

Copyright notice

2015, Royal Society of Chemistry

Issue

32

Publisher

Royal Society of Chemistry

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Keywords

Science & Technology Physical Sciences Chemistry, Multidisciplinary Chemistry School of Medicine 111201 Cancer Cell Biology 920102 Cancer and Related Disorders

Chimeric nucleolin aptamer with survivin DNAzyme for cancer cell targeted delivery

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