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Chronic intestinal pseudo-obstruction in systemic lupus erythematosus due to intestinal smooth muscle myopathy
journal contribution
posted on 2000-01-01, 00:00 authored by P A Hill, Karen DwyerKaren Dwyer, D A PowerWe report the case of a woman with systemic lupus erythematosus initially manifesting with fever, rash and arthritis, and two years later with Class IV lupus nephritis. Following treatment with cyclophosphamide she developed symptoms and signs of chronic intestinal pseudo-obstruction (CIPO) that was initially thought to be due to a neutropenic enterocolitis. However, persistence of symptoms resulted in segmental resection of the ileum which showed widespread myocyte necrosis and active inflammation within the muscularis propria. A subsequent, more extensive ileocolic resection showed severe diffuse atrophy and fibrosis of the muscularis propria throughout the resected bowel. The absence of mesenteric vasculitis and the clinical response of the CIPO to the immunosupressive regimen of prednisolone and cyclosporin A suggest that the bowel muscle coat changes reflect an intestinal myopathy secondary to systemic lupus erythematosus, and may have an auto-immune etiology.
History
Journal
LupusVolume
9Issue
6Pagination
458 - 463Publisher
SAGE PublicationsLocation
London, Eng.Publisher DOI
ISSN
0961-2033Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2000, SAGE PublicationsUsage metrics
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