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Circulating levels of insulin-like growth factors increase and molecular forms of their serum binding proteins change with human pregnancy
journal contribution
posted on 1990-08-16, 00:00 authored by S E Gargosky, K J Moyse, P E Walton, Julie OwensJulie Owens, J C Wallace, J S Robinson, P C OwensInsulin-like growth factors (IGF) and binding proteins were measured in serum from pregnant and nonpregnant women. IGF-I determined by immunoassay after acid-ethanol extraction was increased by pregnancy (p less than 0.005) and was highest in the third trimester (p less than 0.01). Size exclusion chromatography of serum in acid before assay (i) gave a very similar IGF-I pattern, (ii) showed that IGF-II was much higher than IGF-I and (iii) revealed less serum IGF-binding protein activity in pregnancy and lactation. All IGF-binding proteins except binding protein-1 were markedly reduced by pregnancy. This indicates a major change in the main carrier protein for IGFs in the circulation and suggests that tissue targetting of IGFs may be altered during pregnancy.
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Journal
Biochemical and biophysical research communicationsVolume
170Issue
3Pagination
1157 - 1163Publisher
ElsevierLocation
Amsterdam, The NetherlandsPublisher DOI
ISSN
0006-291XLanguage
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
1990, Academic Press Inc.Usage metrics
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