Clay-based formulations for bioavailability enhancement of poorly water-soluble drugs

Clays have been used in various health care products, including drug delivery systems. Advanced formulations
have been investigated to take full advantage of clays or clay-based materials. The remarkable properties of
clays, such as high adsorption, high surface area and high ion exchange capacities, provide an ideal system for the
delivery of poorly water-soluble drugs. Currently, there is still limited information on the classification and discussion
of clay-based formulations for poorly water-soluble drugs. This review aims to describe efficient delivery systems
that use clay as the main excipient in formulations. More details regarding the strategies of using clays in formulations
as well as fabrication methods will be discussed. Moreover, combinations with other excipients in hybrid
formulations will also be mentioned and the efficacy of these systems will be evaluated. The recent studies on claybased
formulations for poorly water-soluble drugs provide fundamental approaches and prospects to be applied in
drug development.