Clinical trials of N-acetylcysteine in psychiatry and neurology: A systematic review.
journal contributionposted on 2015-08-01, 00:00 authored by Deepmala, J Slattery, N Kumar, L Delhey, Michael BerkMichael Berk, Olivia DeanOlivia Dean, C Spielholz, R Frye
N-acetylcysteine (NAC) is recognized for its role in acetaminophen overdose and as a mucolytic. Over the past decade, there has been growing evidence for the use of NAC in treating psychiatric and neurological disorders, considering its role in attenuating pathophysiological processes associated with these disorders, including oxidative stress, apoptosis, mitochondrial dysfunction, neuroinflammation and glutamate and dopamine dysregulation. In this systematic review we find favorable evidence for the use of NAC in several psychiatric and neurological disorders, particularly autism, Alzheimer's disease, cocaine and cannabis addiction, bipolar disorder, depression, trichotillomania, nail biting, skin picking, obsessive-compulsive disorder, schizophrenia, drug-induced neuropathy and progressive myoclonic epilepsy. Disorders such as anxiety, attention deficit hyperactivity disorder and mild traumatic brain injury have preliminary evidence and require larger confirmatory studies while current evidence does not support the use of NAC in gambling, methamphetamine and nicotine addictions and amyotrophic lateral sclerosis. Overall, NAC treatment appears to be safe and tolerable. Further well designed, larger controlled trials are needed for specific psychiatric and neurological disorders where the evidence is favorable.
JournalNeuroscience and Biobehavioral Reviews
Pagination294 - 321
LocationAmsterdam, The Netherlands
Link to full text
Publication classificationC Journal article; C1 Refereed article in a scholarly journal
Copyright notice2015, Elsevier
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Mechanism of actionN-acetylcysteine (NAC)NeurologyPsychiatryScience & TechnologyLife Sciences & BiomedicineBehavioral SciencesNeurosciencesNeurosciences & NeurologyACETYL-L-CYSTEINEMETABOTROPIC GLUTAMATE RECEPTORSPROGRESSIVE MYOCLONUS EPILEPSYCOCAINE-INDUCED REINSTATEMENTEARLY DEPRESSIVE SYMPTOMSPLACEBO-CONTROLLED TRIALFINAL COMMON PATHWAYD-ASPARTATE NMDADOUBLE-BLINDOXIDATIVE STRESS