File(s) under permanent embargo
Cocaine increases stimulation-evoked serotonin efflux in the nucleus accumbens
journal contribution
posted on 2022-03-01, 00:00 authored by J Yuen, A Goyal, A E Rusheen, Abbas KouzaniAbbas Kouzani, Michael BerkMichael Berk, Jee Hyun KimJee Hyun Kim, S J Tye, C D Blaha, K E Bennet, K H Lee, Y Oh, H ShinSerotonin plays a vital role in drug addiction. Here, using N-shaped fast-scan cyclic voltammetry, we demonstrated the effect of cocaine on the phasic release of serotonin at the nucleus accumbens core. To the best of our knowledge, this has not previously been elucidated. Our results not only reinforce the role of serotonin in the mechanism of action of cocaine but also help to fill a gap in our knowledge and provide a baseline for future studies in cocaine addiction.
History
Journal
Journal of neurophysiologyVolume
127Issue
3Pagination
714 - 724Publisher
American Physiological SocietyLocation
United StatesPublisher DOI
ISSN
0022-3077eISSN
1522-1598Language
enPublication classification
C1 Refereed article in a scholarly journalUsage metrics
Read the peer-reviewed publication
Categories
Keywords
addictioncocainenucleus accumbensserotoninvoltammetryScience & TechnologyLife Sciences & BiomedicineNeurosciencesPhysiologyNeurosciences & NeurologySCAN CYCLIC VOLTAMMETRYMEDIAL FOREBRAIN-BUNDLEVENTRAL TEGMENTAL AREANIGRA PARS RETICULATAEXTRACELLULAR DOPAMINEUSE DISORDERMICRODIALYSISRECEPTORSRELEASESYSTEM