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Cognitive functioning in idiopathic generalised epilepsies: a systematic review and meta-analysis
journal contributionposted on 2014-06-01, 00:00 authored by Amy LoughmanAmy Loughman, S C Bowden, W D'Souza
Cognitive function in idiopathic generalised epilepsies (IGE) is of increasing research attention. Current research seeks to understand phenotypic traits associated with this most common group of inherited epilepsies and evaluate educational and occupational trajectories. A specific deficit in executive function in a subgroup of IGE, juvenile myoclonic epilepsy (JME) has been a particular focus of recent research. This systematic review provides a quantitative synthesis of cognitive function outcomes in 26 peer-reviewed, case-control studies published since 1989. Univariate random-effects meta-analyses were conducted on seven cognitive factor-domains and separately on executive function. Patients with IGE demonstrated significantly lower scores on tests across all cognitive factor-domains except visual-spatial abilities. Effect sizes ranged from 0.42 to 0.88 pooled standard deviation units. The average reduction of scores on tests of executive function in IGE compared to controls was 0.72 standard deviation units. Contrary to current thinking, there was no specific deficit in executive function in JME samples, nor in other IGE syndromes. Of more concern, people with IGE are at risk of pervasive cognitive impairment.
JournalNeuroscience & biobehavioral reviews
Pagination20 - 34
LocationAmsterdam, The Netherlands
Publication classificationC1.1 Refereed article in a scholarly journal
Copyright notice2014, Elsevier Ltd.
Childhood absence epilepsy (CAE)CognitionExecutive functionIGE with generalised tonic–clonic seizures onlyIdiopathic generalised epilepsy (IGE)Juvenile myoclonic epilepsy (JME)MemoryBrainEpilepsy, GeneralizedHumansMyoclonic Epilepsy, JuvenileScience & TechnologyLife Sciences & BiomedicineBehavioral SciencesNeurosciencesNeurosciences & NeurologyIGE with generalised tonic-clonic seizures onlyVOXEL-BASED MORPHOMETRYCROSS-BATTERYCLASSIFICATIONEPIDEMIOLOGYSEIZURES