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Cognitive functioning in idiopathic generalised epilepsies: a systematic review and meta-analysis
journal contribution
posted on 2014-06-01, 00:00 authored by Amy LoughmanAmy Loughman, S C Bowden, W D'SouzaCognitive function in idiopathic generalised epilepsies (IGE) is of increasing research attention. Current research seeks to understand phenotypic traits associated with this most common group of inherited epilepsies and evaluate educational and occupational trajectories. A specific deficit in executive function in a subgroup of IGE, juvenile myoclonic epilepsy (JME) has been a particular focus of recent research. This systematic review provides a quantitative synthesis of cognitive function outcomes in 26 peer-reviewed, case-control studies published since 1989. Univariate random-effects meta-analyses were conducted on seven cognitive factor-domains and separately on executive function. Patients with IGE demonstrated significantly lower scores on tests across all cognitive factor-domains except visual-spatial abilities. Effect sizes ranged from 0.42 to 0.88 pooled standard deviation units. The average reduction of scores on tests of executive function in IGE compared to controls was 0.72 standard deviation units. Contrary to current thinking, there was no specific deficit in executive function in JME samples, nor in other IGE syndromes. Of more concern, people with IGE are at risk of pervasive cognitive impairment.
History
Journal
Neuroscience & biobehavioral reviewsVolume
43Pagination
20 - 34Publisher
ElsevierLocation
Amsterdam, The NetherlandsPublisher DOI
ISSN
0149-7634eISSN
1873-7528Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2014, Elsevier Ltd.Usage metrics
Categories
Keywords
Childhood absence epilepsy (CAE)CognitionExecutive functionIGE with generalised tonic–clonic seizures onlyIdiopathic generalised epilepsy (IGE)Juvenile myoclonic epilepsy (JME)MemoryBrainEpilepsy, GeneralizedHumansMyoclonic Epilepsy, JuvenileScience & TechnologyLife Sciences & BiomedicineBehavioral SciencesNeurosciencesNeurosciences & NeurologyIGE with generalised tonic-clonic seizures onlyVOXEL-BASED MORPHOMETRYCROSS-BATTERYCLASSIFICATIONEPIDEMIOLOGYSEIZURES