Deakin University
Browse

Cohort profile: the Barwon infant study

Download (381.42 kB)
Version 2 2024-06-04, 02:13
Version 1 2016-02-23, 12:50
journal contribution
posted on 2024-06-04, 02:13 authored by Peter VuillerminPeter Vuillermin, R Saffery, KJ Allen, JB Carlin, MLK Tang, S Ranganathan, D Burgner, T Dwyer, Fiona CollierFiona Collier, K Jachno, P Sly, C Symeonides, Kate MccloskeyKate Mccloskey, J Molloy, Mike ForresterMike Forrester, A-L Ponsonby
The modern environment is associated with an increasing burden of non-communicable diseases (NCDs). Mounting evidence implicates environmental exposures, experienced early in life (including in utero), in the aetiology of many NCDs, though the cellular/molecular mechanism(s) underlying this elevated risk across the life course remain unclear. Epigenetic variation has emerged as a candidate mediator of such effects. The Barwon Infant Study (BIS) is a population-derived birth cohort study (n ¼ 1074 infants) with ante-natal recruitment, conducted in the south-east of Australia (Victoria). BIS has been designed to facilitate a detailed mechanistic investigation of development within an epidemiological framework. The broad objectives are to investigate the role of specific environmental factors, gut microbiota and epigenetic variation in early-life development, and subsequent immune, allergic, cardiovascular, respiratory and neurodevelopmental outcomes. Participants have been reviewed at birth and at 1, 6, 9 and 12 months, with 2-and 4-year reviews under way. Biological samples and measures include: maternal blood, faeces and urine during pregnancy; infant urine, faeces and blood at regular intervals during the first 4 years; lung function at 1 month and 4 years; cardiovascular assessment at 1 month and 4 years; skin-prick allergy testing and food challenge at 1 year; and neurodevelopmental assessment at 9 months, 2 and 4 years. Data access enquiries can be made at [www.barwoninfantstudy.org.au] or via [peter.vuillermin@deakin.edu.au].

History

Journal

International journal of epidemiology

Volume

44

Pagination

1148-1160

Location

Oxford, Eng.

Open access

  • Yes

ISSN

0300-5771

Language

eng

Publication classification

C Journal article, C1 Refereed article in a scholarly journal

Copyright notice

2015, Oxford University Press

Issue

4

Publisher

Oxford University Press

Usage metrics

    Research Publications

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC