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Cohort profile: the HealthNuts study: population prevalence and environmental/genetic predictors of food allergy

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journal contribution
posted on 2015-08-01, 00:00 authored by J J Koplin, M Wake, S C Dharmage, M Matheson, M L K Tang, L C Gurrin, T Dwyer, R L Peters, S Prescott, A-L Ponsonby, A J Lowe, K J Allen, D Hill, Peter VuillerminPeter Vuillermin, HealthNuts study group
HealthNuts is a single-centre, multi-wave, population-based longitudinal study designed to assess prevalence, determinants, natural history and burden of allergy (particularly food allergy) in the early years of life. It is novel in the use of serial food challenge measures within its population frame to confirm food allergy. The cohort comprises 5276 children initially recruited at age 12 months from council-run immunization sessions across Melbourne, Australia. As well as parent-completed questionnaires and researcher-observed eczema status, all infants underwent skin-prick testing to egg, peanut, sesame and either cow's milk or shellfish, and those with detectable wheals underwent food challenges to determine clinical allergy. In wave 2, conducted at age 4 years, validated questionnaires collected data on asthma, allergic rhinitis (hay fever), eczema and food allergies. Food challenges were repeated in children previously identified as food allergic to determine resolution. In wave 3, all children (irrespective of food allergy status) were invited for clinical assessment at age 6 years, including lung function, physical measurements, skin-prick testing to foods and aeroallergens and food challenges if food sensitized. Biological specimens (blood, cheek swabs) were collected at each wave for ancillary immunological, genetic and epigenetic studies.

History

Journal

International Journal of Epidemiology

Volume

44

Issue

4

Pagination

1161 - 1171

Publisher

Oxford University Press

Location

Oxford, Eng.

ISSN

0300-5771

eISSN

1464-3685

Language

eng

Publication classification

C Journal article; C1.1 Refereed article in a scholarly journal

Copyright notice

2015, The Author