File(s) under permanent embargo
Community-onset Staphylococcus aureus infections presenting to general practices in South-eastern Australia
journal contribution
posted on 2013-07-18, 00:00 authored by Catherine BennettCatherine Bennett, G Coombs, G Wood, B Howden, L Johnson, D White, P JohnsonCommunity-acquired Staphylococcus aureus infections are a public health concern, yet little is known about infections that do not present to hospital. We identified community-onset S. aureus infections via specimens submitted to a community-based pathology service. Referring doctors confirmed eligibility and described infection site, severity and treatment. Isolates were characterized on antibiotic resistance, PFGE, MLST/SCCmec, and Panton–Valentine leukocidin (PVL), representing 106 community-onset infections; 34 non-multiresistant methicillin-resistant S. aureus (nmMRSA) (resistant to <3 non-β-lactam antibiotics), 15 multiply antibiotic-resistant MRSA (mMRSA) and 57 methicillin-sensitive S. aureus (MSSA). Most (93%) were skin and soft tissue infections. PVL genes were carried by 42% of nmMRSA isolates [95% confidence interval (CI) 26–61] and 15% of MSSA (95% CI 8–28). PVL was associated with infections of the trunk, head or neck (56·4% vs. 24·3%, P= 0·005) in younger patients (23 vs. 52 years, P< 0·001), and with boils or abscesses (OR 8·67, 95% CI 2·9–26·2), suggesting underlying differences in exposure and/or pathogenesis.
History
Journal
Epidemiology and infectionVolume
142Issue
3Pagination
501 - 511Publisher
Cambridge University PressLocation
Cambridge, EnglandPublisher DOI
ISSN
0950-2688eISSN
1469-4409Language
engPublication classification
C1.1 Refereed article in a scholarly journalUsage metrics
Categories
No categories selectedKeywords
epidermiologymethicillin-resistantpublic health emerging infectionsstaphylococcal infectionsStaphylococcus aureusScience & TechnologyLife Sciences & BiomedicinePublic, Environmental & Occupational HealthInfectious Diseasesmethicillin-resistant S. aureus (MRSA)EpidemiologyPANTON-VALENTINE LEUKOCIDINSOFT-TISSUE INFECTIONSNECROTIZING PNEUMONIACLONAL COMPLEXBACTEREMIASKINASSOCIATIONMORTALITYSTRAINS
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC