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Comparative aspects of natriuretic peptide physiology in non-mammalian vertebrates: a review

journal contribution
posted on 2004-04-01, 00:00 authored by Marie-Therese Toop, John DonaldJohn Donald
The natriuretic peptide system is a complex family of peptides and receptors that is primarily linked to the maintenance of osmotic and cardiovascular homeostasis. A natriuretic peptide system is present in each vertebrate class but there are varying degrees of complexity in the system. In agnathans and chondrichthyians, only one natriuretic peptide has been identified, while new data has revealed that multiple types of natriuretic peptides are present in bony fish. However, it seems in tetrapods that there has been a reduction in the number of natriuretic peptide genes, such that only three natriuretic peptides are present in mammals. The peptides act via a family of guanylyl cyclase receptors to generate the second messenger cGMP, which  mediates a range of physiological effects at key targets such as the gills, kidney and the cardiovascular system. This review summarises the current knowledge of the natriuretic peptide system in non-mammalian vertebrates and discusses the physiological actions of the peptides.

History

Journal

Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology

Volume

174

Issue

3

Pagination

189 - 204

Publisher

Spring-Verlag

Location

Berlin, Germany

ISSN

0174-1578

eISSN

1432-136X

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2004, Springer-Verlag