angelova-complexityanalysis-2014.pdf (833.3 kB)
Complexity analysis of sleep and alterations with insomnia based on non-invasive techniques
journal contribution
posted on 2014-04-06, 00:00 authored by P M Holloway, Maia Angelova TurkedjievaMaia Angelova Turkedjieva, S Lombardo, A St Clair Gibson, D Lee, J EllisFor the first time, fractal analysis techniques are implemented to study the correlations present in sleep actigraphy for individuals suffering from acute insomnia with comparisons made against healthy subjects. Analysis was carried out for 21 healthy individuals with no diagnosed sleep disorders and 26 subjects diagnosed with acute insomnia during night-time hours. Detrended fluctuation analysis was applied in order to look for 1/f-fluctuations indicative of high complexity. The aim is to investigate whether complexity analysis can differentiate between people who sleep normally and people who suffer from acute insomnia. We hypothesize that the complexity will be higher in subjects who suffer from acute insomnia owing to increased night-time arousals. This hypothesis, although contrary to much of the literature surrounding complexity in physiology, was found to be correct-for our study. The complexity results for nearly all of the subjects fell within a 1/f-range, indicating the presence of underlying control mechanisms. The subjects with acute insomnia displayed significantly higher correlations, confirmed by significance testing-possibly a result of too much activity in the underlying regulatory systems. Moreover, we found a linear relationship between complexity and variability, both of which increased with the onset of insomnia. Complexity analysis is very promising and could prove to be a useful non-invasive identifier for people who suffer from sleep disorders such as insomnia.
History
Journal
Journal of the Royal Society: interfaceVolume
11Issue
93Article number
20131112Pagination
1 - 8Publisher
Royal Society PublishingLocation
London, Eng.Publisher DOI
Link to full text
ISSN
1742-5689eISSN
1742-5662Language
engPublication classification
C Journal article; C1.1 Refereed article in a scholarly journalCopyright notice
2014, The AuthorsUsage metrics
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No categories selectedKeywords
sleepinsomniacomplexity1\/f-fluctuationsdetrended fluctuation analysisactigraphAdolescentAdultFemaleHumansMaleMiddle AgedModels, BiologicalSleep Initiation and Maintenance DisordersScience & TechnologyMultidisciplinary SciencesScience & Technology - Other TopicsHEART-RATE-VARIABILITYFRACTAL DYNAMICSACTIGRAPHYMAGNITUDEPATTERNSDAYTIMEAPNEA
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