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Comprehensive two-dimensional liquid chromatography

journal contribution
posted on 2006-10-01, 00:00 authored by Robert Shellie, P R Haddad
Having nearly exhausted the possibilities for generating peak capacity through improvements in column technology, chromatographers are increasingly looking to alternative ways of maximising chromatographic separation. In recent years there has been increasing activity in the field of comprehensive multidimensional separations to meet analysis demands. Comprehensive two-dimensional liquid chromatography (LC×LC) approaches offer high peak capacity which leads to significantly improved analytical performance over single-column liquid chromatography. There are several closely related avenues available for achieving an LC×LC separation and this review pays special attention to the different valve-based interfaces that have been used to comprehensively couple the first and second dimension columns in LC×LC systems. A brief discussion of column choices for selected applications and the conditions employed is also presented. © Springer-Verlag 2006.

History

Journal

Analytical and bioanalytical chemistry

Volume

386

Issue

3

Pagination

405 - 415

Publisher

Springer

Location

Cham, Switzerland

ISSN

1618-2642

eISSN

1618-2650

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal