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Comprehensive two-dimensional liquid chromatography
journal contribution
posted on 2006-10-01, 00:00 authored by Robert Shellie, P R HaddadHaving nearly exhausted the possibilities for generating peak capacity through improvements in column technology, chromatographers are increasingly looking to alternative ways of maximising chromatographic separation. In recent years there has been increasing activity in the field of comprehensive multidimensional separations to meet analysis demands. Comprehensive two-dimensional liquid chromatography (LC×LC) approaches offer high peak capacity which leads to significantly improved analytical performance over single-column liquid chromatography. There are several closely related avenues available for achieving an LC×LC separation and this review pays special attention to the different valve-based interfaces that have been used to comprehensively couple the first and second dimension columns in LC×LC systems. A brief discussion of column choices for selected applications and the conditions employed is also presented. © Springer-Verlag 2006.
History
Journal
Analytical and bioanalytical chemistryVolume
386Issue
3Pagination
405 - 415Publisher
SpringerLocation
Cham, SwitzerlandPublisher DOI
ISSN
1618-2642eISSN
1618-2650Language
engPublication classification
C1.1 Refereed article in a scholarly journalUsage metrics
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No categories selectedKeywords
Science & TechnologyLife Sciences & BiomedicinePhysical SciencesBiochemical Research MethodsChemistry, AnalyticalBiochemistry & Molecular BiologyChemistryliquid chromatographyHPLCcomprehensive two-dimensional liquid chromatographyLCxLCmultidimensional chromatographypeak capacityPEAK-CAPACITYPERFORMANCESEPARATIONRESOLUTIONCOLUMNIDENTIFICATION
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