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Confirmation of a relationship between reduced auditory P300 amplitude and thought disorder in schizophrenia

journal contribution
posted on 15.12.2005, 00:00 authored by K Kirihara, T Araki, K Kasai, K Maeda, A Hata, M Uetsuki, H Yamasue, Mark RogersMark Rogers, N Kato, A Iwanami
We have previously reported an association between reduced amplitude of auditory P300 event-related potential and severity of positive thought disorder as assessed by the Comprehensive Index of Positive Thought Disorder in a sample of patients with chronic schizophrenia. Here we replicate those findings using a different measure, Thought Disorder Index (TDI), in a new larger sample of 55 patients. The auditory P300 amplitude showed a significant negative correlation with scores on TDI. This correlation was relatively more pronounced in the left temporal region than in the right temporal region. These results further suggest that electrophysiological abnormalities of information processing may underlie positive thought disorder in schizophrenia.

History

Journal

Schizophrenia research

Volume

80

Issue

2-3

Pagination

197 - 201

Publisher

Elsevier

Location

Amsterdam, The Netherlands

ISSN

0920-9964

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

2005, Elsevier