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Confirmation of a relationship between reduced auditory P300 amplitude and thought disorder in schizophrenia
journal contribution
posted on 2005-12-15, 00:00 authored by K Kirihara, T Araki, K Kasai, K Maeda, A Hata, M Uetsuki, H Yamasue, Mark RogersMark Rogers, N Kato, A IwanamiWe have previously reported an association between reduced amplitude of auditory P300 event-related potential and severity of positive thought disorder as assessed by the Comprehensive Index of Positive Thought Disorder in a sample of patients with chronic schizophrenia. Here we replicate those findings using a different measure, Thought Disorder Index (TDI), in a new larger sample of 55 patients. The auditory P300 amplitude showed a significant negative correlation with scores on TDI. This correlation was relatively more pronounced in the left temporal region than in the right temporal region. These results further suggest that electrophysiological abnormalities of information processing may underlie positive thought disorder in schizophrenia.
History
Journal
Schizophrenia researchVolume
80Issue
2-3Pagination
197 - 201Publisher
ElsevierLocation
Amsterdam, The NetherlandsPublisher DOI
ISSN
0920-9964Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2005, ElsevierUsage metrics
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