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Conjugation strategies for colonic delivery and its application in colorectal cancer therapy

Version 2 2024-06-04, 11:45
Version 1 2018-06-05, 14:20
journal contribution
posted on 2024-06-04, 11:45 authored by PHL Tran, Wei DuanWei Duan, TTD Tran
BACKGROUND: Efficient colon-specific drug delivery has been demonstrated recently in the treatment of various diseases, including Crohn's disease, ulcerative colitis (inflammatory bowel disease), and colorectal cancer. METHODS: Of all strategies, the conjugation of a model drug to a carrier (with or without spacers) has been recognized as promising for targeting the colon. RESULTS: This is because the conjugation method releases large amounts of the drug while reducing the amount of the drug released in the stomach and small intestine. CONCLUSION: This review focuses on the design of linkage conjugates that carry out specific delivery to the colon. The types of conjugation for application in colorectal cancer therapy will be discussed as well.

History

Journal

Current drug metabolism

Volume

18

Pagination

1016-1019

Location

Beijing, China

ISSN

1389-2002

eISSN

1875-5453

Language

eng

Publication classification

C Journal article, C1 Refereed article in a scholarly journal

Copyright notice

[2017, Bentham Science Publishers]

Issue

11

Publisher

Bentham Science Publishers