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Controlled release of heparin from polypyrrole-poly(vinyl alcohol) assembly by electrical stimulation

Version 2 2024-06-13, 13:07
Version 1 2019-07-18, 12:58
journal contribution
posted on 2024-06-13, 13:07 authored by Y Li, KG Neoh, ET Kang
A surface modification technique was developed for the covalent immobilization of poly(vinyl alcohol) (PVA)-heparin hydrogel onto electrically conductive polypyrrole (PPY) film with the objective of achieving controlled release of heparin. First, aldehyde groups were introduced onto PPY film through poly(ethylene glycol) monomethacrylate graft copolymerization and subsequent oxidation in acetic anhydride and dimethyl sulfoxide mixture. Then, the prepared PVA-heparin hydrogel was cast onto the PPY film and covalently immobilized to the film through the reaction between the aldehyde groups on the PPY film and the hydroxyl groups of PVA. X-ray photoelectron spectroscopy was used to characterize the surface-modified film after each stage. The strong attachment of the PVA-heparin layer on the PPY film was confirmed by peel test and scanning electron microscopy. The release behavior of heparin from the substrate with and without electrical stimulation was studied and the experimental results showed that the heparin release rate from the prepared substrate using an electric current of 3.5 mA is twofold higher than that without current.

History

Journal

Journal of biomedical materials research : part A

Volume

73A

Pagination

171-181

Location

Chichester, Eng.

ISSN

0021-9304

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

2005, Wiley Periodicals, Inc

Issue

2

Publisher

John Wiley & Sons

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