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Controlled release systems containing solid dispersions: strategies and mechanisms
journal contribution
posted on 2011-10-01, 00:00 authored by Phuong TranPhuong Tran, T T-D Tran, J B Park, B-J LeeIn addition to a number of highly soluble drugs, most new chemical entities under development are poorly water-soluble drugs generally characterized by an insufficient dissolution rate and a small absorption window, leading to the low bioavailability. Controlled-release (CR) formulations have several potential advantages over conventional dosage forms, such as providing a uniform and prolonged therapeutic effect to improve patient compliance, reducing the frequency of dosing, minimizing the number of side effects, and reducing the strength of the required dose while increasing the effectiveness of the drug. Solid dispersions (SD) can be used to enhance the dissolution rate of poorly water-soluble drugs and to sustain the drug release by choosing an appropriate carrier. Thus, a CR-SD comprises both functions of SD and CR for poorly water-soluble drugs. Such CR dosage forms containing SD provide an immediately available dose for an immediate action followed by a gradual and continuous release of subsequent doses to maintain the plasma concentration of poorly water-soluble drugs over an extended period of time. This review aims to summarize all currently known aspects of controlled release systems containing solid dispersions, focusing on the preparation methods, mechanisms of action and characterization of physicochemical properties of the system.
History
Journal
Pharmaceutical researchVolume
28Issue
10Pagination
2353 - 2378Publisher
SpringerLocation
Berlin, GermanyPublisher DOI
eISSN
1573-904XLanguage
engPublication classification
C1.1 Refereed article in a scholarly journal; C Journal articleCopyright notice
2011, SpringerUsage metrics
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No categories selectedKeywords
Delayed-Action PreparationsDrug CarriersHumansPharmaceutical PreparationsSolubilityScience & TechnologyPhysical SciencesLife Sciences & BiomedicineChemistry, MultidisciplinaryPharmacology & PharmacyChemistrycontrolled release solid dispersionpoorly water-soluble drugsmanufacturing methodsphysicochemical characterizationrate-controlling mechanismWATER-SOLUBLE DRUGSELF-EMULSIFYING FORMULATIONHYDROPHILIC MATRIX TABLETSWEAKLY BASIC DRUGSUSTAINED-RELEASEIN-VITRODOSAGE FORMSSODIUM ALGINATEEUDRAGIT RSMICROENVIRONMENTAL PH
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