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Creatine supplementation and riluzole treatment provide similar beneficial effects in copper, zinc superoxide dismutase (G93A) transgenic mice

journal contribution
posted on 2003-07-04, 00:00 authored by Rod SnowRod Snow, J Turnbull, S Da Silva, F Jiang, M Tarnopolsky
This study investigated the effects of riluzole (Ril), creatine (Cr) and a combination of these treatments on the onset and progression of clinical signs and neuropathology in an animal model of familial amyotrophic lateral sclerosis, the G93A transgenic mouse (n=13–17 per group). The onset of clinical signs was delayed (P<0.05) by about 12 days in all treatment groups compared with control; however, no differences occurred between treatments. All animals were killed at 199 days of age. At the end of the experimental period the severity of clinical signs was less (P<0.05) with all treatments compared with control. Again no differences between treatments were observed. The treatments had no effect on the number of neurons in ventral horns of the lumbar region of the spinal cord. Transgenic mice ingesting Cr displayed elevated (P<0.05) total Cr levels in cerebral hemispheres (5%) and spinal cord (8%), but not skeletal muscles. These data demonstrate that treatment with Ril and Cr were both effective in delaying disease onset and clinical disability. To the age of killing, no additional benefit was conferred by co-administration of Ril and Cr.

History

Journal

Neuroscience

Volume

119

Issue

3

Pagination

661 - 667

Publisher

Elsevier BV

Location

Amsterdam, Netherlands

ISSN

0306-4522

eISSN

1873-7544

Language

eng

Notes

Available online 23 May 2003.

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2003, IBRO