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Cross-sectional and longitudinal associations between gut microbiota composition and cognition in the second year of life: Findings from the Child Health and Resident Microbes study
journal contribution
posted on 2023-02-09, 02:03 authored by M Matsuyama, N Murtaza, M Morrison, PSW Davies, RJ Hill, Amy LoughmanAmy LoughmanThe relationship between the gut microbiota and brain function are receiving increasing research attention. Studies investigating gut microbiota and early childhood neurocognition are limited, particularly in longitudinal measurements. We examined cross-sectional relationships between gut microbiota of a cohort of otherwise healthy children using 16S rRNA sequencing and their cognitive development measured with Bayley's Scales of Infant Development III at 24 months of age (n = 43), and longitudinal relationships between gut microbiota composition at 12 months (n = 41) of age and neurodevelopment at 24 months of age. Associations between gut microbiota characteristics and cognitive development were observed both cross-sectionally and longitudinally, notably with butyrate producing bacteria among some children. Bacterial diversity varied between cross-sectional and longitudinal observations, where the gut microbiota community of children with lower cognitive scores had a trend toward higher alpha diversity, whereas, in the longitudinal observation, a trend toward reduced alpha diversity was observed. This study is limited by a small sample size and its exploratory nature. Yet, the study contributes to knowledge in the gut microbiota characteristics and early life neurodevelopment, a field of study which is underexplored, presenting opportunities for future larger specific studies.
History
Journal
American Journal of Medical Genetics, Part B: Neuropsychiatric GeneticsVolume
189Pagination
285-292Location
London, Eng.Publisher DOI
ISSN
1552-4841eISSN
1552-485XLanguage
EnglishPublication classification
C1 Refereed article in a scholarly journalIssue
7-8Publisher
WileyUsage metrics
Keywords
child developmentcognitionDIRECTED ACYCLIC GRAPHSgastrointestinal microbiomeGenetics & HeredityGUIDELINESINFERENCELife Sciences & BiomedicinePsychiatryScience & TechnologySTATEMENTTEMPERAMENTNeurosciencesBasic Behavioral and Social ScienceClinical ResearchPreventionPediatricPediatric Research InitiativeBehavioral and Social ScienceMind and Body1 Underpinning research1.1 Normal biological development and functioningMental healthOral and gastrointestinal