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Cucurbitacins, cell adhesion inhibitors from Conobea scoparioides
journal contribution
posted on 1994-11-01, 00:00 authored by L L Musza, P Speight, S McElhiney, Colin BarrowColin Barrow, A M Gillum, R Cooper, L M KillarIn the course of screening natural products for antagonists of CD18-mediated cell adhesion, an extract with inhibitory activity was identified from the stem and leaves of Conobea scoparioides. Bioassay-guided fractionation led to a pure compound, identified by spectroscopy as cucurbitacin E [1]. Although many biological activities have been reported for the cucurbitacins, this is the first report of cell adhesion inhibition. Furthermore, closely related cucurbitacin analogues had different potencies, pointing to substructural features that are important for the activity.
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Journal
Journal of natural productsVolume
57Issue
11Pagination
1498 - 1502Publisher
American Chemical SocietyLocation
Washington, D.C.Publisher DOI
ISSN
0163-3864Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
[1994, American Chemical Society]Usage metrics
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