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Cucurmin, anticancer, & antitumor perspectives: a comprehensive review

journal contribution
posted on 2017-08-01, 00:00 authored by M Imran, A Ullah, F Saeed, M Nadeem, M U Arshad, Hafiz SuleriaHafiz Suleria
Cucurmin, a naturally yellow component isolated from turmeric, ability to prevent various life-style related disorders. The current review article mainly emphasizes on different anticancer perspectives of cucurmin, i.e., colon, cervical, uterine, ovarian, prostate head and neck, breast, pulmonary, stomach and gastric, pancreatic, bladder oral, oesophageal, and bone cancer. It holds a mixture of strong bioactive molecule known as cucurminoids that has ability to reduce cancer/tumor at initial, promotion and progression stages of tumor development. In particular, these compounds block several enzymes required for the growth of tumors and may therefore involve in tumor treatments. Moreover, it modulates an array of cellular progressions, i.e., nitric oxide synthetase activity, protein kinase C activity, epidermal growth factor (EGF) receptor intrinsic kinase activity, nuclear factor kappa (NF-kB) activity, inhibiting lipid peroxidation and production of reactive oxygen species. However, current manuscript summarizes most of the recent investigations of cucurmin but still further research should be conducted to explore the role of curcumin to mitigate various cancers.

History

Journal

Critical reviews in food science and nutrition

Volume

58

Issue

8

Pagination

1271 - 1293

Publisher

Taylor & Francis

Location

Abingdon, Eng.

ISSN

1040-8398

eISSN

1549-7852

Language

eng

Publication classification

C Journal article; C1.1 Refereed article in a scholarly journal

Copyright notice

2018, Taylor & Francis