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Current perspectives in Set7 mediated stem cell differentiation

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journal contribution
posted on 2016-12-04, 00:00 authored by Nazanin Karimnia, Haloom Rafehi, Natasha K Tuano, Mark ZiemannMark Ziemann, Harikrishnan K N, Jun Okabe, Assam El-Osta
Set7 is a key regulatory enzyme involved in the methylation of lysine residues of histone and non-histone proteins. This lysine methyltransferase is induced during stem cell differentiation and regulates lineage specific gene transcription and cell fate. In this article we discuss recent experimental evidence identifying regulatory targets under the control of Set7 as well as emerging evidence of regulation in stem cell differentiation. Furthermore, we discuss the function of non-coding RNAs regulated by Set7 implicated in cell plasticity.

History

Journal

Non-coding RNA

Volume

2

Pagination

1-8

Location

Basel, Switzerland

Open access

  • Yes

eISSN

2311-553X

Language

eng

Publication classification

C Journal article, C1.1 Refereed article in a scholarly journal

Copyright notice

2016, the authors

Issue

4

Publisher

MDPI

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