File(s) under permanent embargo
Cyclic AMP inhibits expression of D-Type cyclins and cdk4 and induces p27(Kip1) in G-CSF-Treated NFS-60 cells
Version 2 2024-06-03, 21:45
Version 1 2017-05-16, 15:55
journal contribution
posted on 2024-06-03, 21:45 authored by Alister WardAlister Ward, XF Csar, BW Hoffmann, JA HamiltonThe addition of cAMP inhibits G-CSF-mediated proliferation and suppresses pRB phosphorylation in NFS-60 cells. We show that the latter could be attributed to different effects of cAMP in these cells: (i) down-regulation of the levels of cyclins D2 and D3, and cdk4, and (ii) induction of the p27Kip1 inhibitor of cdk4.
History
Journal
Biochemical and Biophysical Research CommunicationsVolume
224Pagination
10-16Location
United StatesPublisher DOI
ISSN
0006-291XeISSN
1090-2104Language
EnglishPublication classification
CN.1 Other journal articleIssue
1Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCEUsage metrics
Categories
Keywords
Science & TechnologyLife Sciences & BiomedicineBiochemistry & Molecular BiologyBiophysicsDEPENDENT PROTEIN-KINASESSTIMULATING FACTOR-ISMOOTH-MUSCLE CELLSRETINOBLASTOMA PROTEINDNA-SYNTHESISGROWTH-FACTORG(1) CYCLINSPHASEPROLIFERATIONFIBROBLASTS1-Methyl-3-isobutylxanthine8-Bromo Cyclic Adenosine MonophosphateAnimalsBlotting, NorthernCell Cycle ProteinsCell DivisionCell LineCyclic AMPCyclin DCyclin-Dependent Kinase 4Cyclin-Dependent Kinase Inhibitor p27Cyclin-Dependent KinasesCyclinsDNADinoprostoneDose-Response Relationship, DrugGenes, Tumor SuppressorGranulocyte Colony-Stimulating FactorKineticsMicrotubule-Associated ProteinsPhosphorylationProto-Oncogene ProteinsTumor Suppressor Proteins
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC