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Cytokine receptor signaling through the Jak-Stat-Socs pathway in disease
journal contribution
posted on 2007-04-01, 00:00 authored by L O`Sullivan, Clifford LiongueClifford Liongue, Rowena Lord, S Stephenson, Alister WardAlister WardThe complexity of multicellular organisms is dependent on systems enabling cells to respond to specific stimuli. Cytokines and their receptors are one such system, whose perturbation can lead to a variety of disease states. This review represents an overview of our current understanding of the cytokine receptors, Janus kinases (Jaks), Signal transducers and activators of transcription (Stats) and Suppressors of cytokine signaling (Socs), focussing on their contribution to diseases of an immune or hematologic nature.
History
Journal
Molecular immunologyVolume
44Issue
10Pagination
2497 - 2506Publisher
Pergamon - ElsevierLocation
Oxford, EnglandPublisher DOI
ISSN
0161-5890eISSN
1872-9142Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2006, Elsevier LtdUsage metrics
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Categories
Keywords
cytokine receptorJak–Stat–Socsinflammatory diseasesScience & TechnologyLife Sciences & BiomedicineBiochemistry & Molecular BiologyImmunologyJak-Stat-SocsCOLONY-STIMULATING-FACTORSEVERE COMBINED IMMUNODEFICIENCYCELL-SURFACE RECEPTORSACUTE MYELOID-LEUKEMIATYROSINE KINASE JAK2G-CSF RECEPTORCONSTITUTIVE ACTIVATIONEXTRACELLULAR DOMAININTERFERON-ALPHALEPTIN RECEPTOR