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DNA methylation analysis of candidate genes associated with dementia in peripheral blood

Version 2 2024-06-06, 01:51
Version 1 2022-04-01, 08:27
journal contribution
posted on 2024-06-06, 01:51 authored by Peter FransquetPeter Fransquet, P Lacaze, R Saffery, J Phung, E Parker, RC Shah, A Murray, RL Woods, J Ryan
Aim: To investigate whether genes implicated in dementia pathogenesis are differently methylated in peripheral blood. Materials & methods: Participants included 160 cognitively healthy individuals aged 70+ years: 73 who were subsequently diagnosed with dementia and 87 controls matched on age, gender, education, smoking and baseline cognition. A total of 49 participants also provided blood samples at diagnosis. Blood DNA methylation of APOE, APP, BDNF, PIN1, SNCA and TOMM40 was examined. Results: A total of 56 of 299 probes were differentially methylated in dementia compared with controls and 39 probes prior to diagnosis. The greatest effect size was in APP (cg19423170, Δ-8.32%, adjusted p = 0.009 at diagnosis; cg19933173, Δ-4.18%, adjusted p < 0.0001 prediagnosis). Conclusion: Genes implicated in dementia pathogenesis show differential blood methylation in dementia, even prior to diagnosis.

History

Journal

Epigenomics

Volume

12

Pagination

2109-2123

Location

London, Eng.

ISSN

1750-1911

eISSN

1750-192X

Language

English

Publication classification

C1 Refereed article in a scholarly journal

Issue

23

Publisher

Future Medicine