File(s) not publicly available
Delirium due to hip fracture is associated with activated immune-inflammatory pathways and a reduction in negative immunoregulatory mechanisms
journal contribution
posted on 2023-02-20, 01:37 authored by Paul Thisayakorn, Yanin Thipakorn, Saran Tantavisut, Sunee Sirivichayakul, Michael MaesAbstract
Background
The objectives of this study were to delineate whether delirium in older adults is associated with activation of the immune-inflammatory response system (IRS) as indicated by activation of M1, T helper (Th)1, and Th17 profiles, and/or by reduced activities of the compensatory immunoregulatory system (CIRS), including Th2 and T regulatory profiles.
Methods
We recruited 65 older adult patients with a low energy impact hip fracture who underwent hip fracture operation. The CAM-ICU and the Delirium Rating Scale, Revised-98-Thai version (DRS-R-98) were assessed pre-operatively and 1, 2 and 3 days after surgery. Blood samples (day 1 and 2) post-surgery were assayed for cytokines/chemokines using a MultiPlex assay and the neutrophil/lymphocyte ratio.
Results
We found that delirium and/or the DRS-R-98 score were associated with IRS activation as indicated by activated M1, Th1, Th17 and T cell growth profiles and by attenuated CIRS functions. The most important IRS biomarkers were CXCL8, interleukin (IL)-6, and tumor necrosis factor-α, and the most important CIRS biomarkers were IL-4 and soluble IL-1 receptor antagonist. We found that 42.5% of the variance in the actual changes in the DRS-R-98 score (averaged from day 1 to day 3) was explained by T cell growth factors, baseline DRS-R-98 scores and age. An increase in the NLR reflects overall IRS, M1, Th1, Th17, and Th2 activation.
Conclusions
Post-hip surgery delirium is associated with activated IRS pathways and appears especially in patients with lowered CIRS functions.
History
Journal
BMC PSYCHIATRYVolume
22Article number
ARTN 369Location
EnglandPublisher DOI
ISSN
1471-244XeISSN
1471-244XLanguage
EnglishPublication classification
C1 Refereed article in a scholarly journalIssue
1Publisher
BMCUsage metrics
Categories
Keywords
Science & TechnologyLife Sciences & BiomedicinePsychiatryDeliriumHip fractureInflammationCytokinesBiomarkersNeuroimmuneNeurocognitionC-REACTIVE PROTEINPOSTOPERATIVE DELIRIUMSYSTEMIC INFLAMMATIONPREOPERATIVE DELIRIUMRECEPTOR ANTAGONISTNEUROINFLAMMATIONSURGERYINTERLEUKIN-1-BETAPATHOPHYSIOLOGYDEPRESSIONAgedHip FracturesHumansTumor Necrosis Factor-alphaAgingClinical ResearchInflammatory and immune systemPublic Health and Health Services not elsewhere classifiedClinical Sciences not elsewhere classifiedPsychology not elsewhere classified