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Deserters on the atopic march: risk factors, immune profile, and clinical outcomes of food‐sensitized‐tolerant infants

journal contribution
posted on 2020-06-01, 00:00 authored by Lawrence GrayLawrence Gray, Anne Louise Ponsonby, Fiona Collier, Martin O'HelyMartin O'Hely, Peter D Sly, Sarath Ranganathan, Mimi L K Tang, John B Carlin, Richard Saffery, Peter VuillerminPeter Vuillermin, David Burgner, Katrina J Allen, Angela Pezic
Background
A few studies have investigated the antecedents and outcomes of infants who demonstrate IgE sensitization to foods that they clinically tolerate. Improved understanding of this sensitized‐tolerant phenotype may inform strategies for the prevention of food allergy.

Methods
In an Australian birth cohort (n = 1074), assembled using an unselected antenatal sampling frame, participants were categorized as nonsensitized (NS), sensitizedtolerant (ST), or food allergic (FA) based on skin prick testing and food challenge at 12 months of age. Environmental exposures were recorded throughout. Cord blood regulatory T‐cell populations were measured at birth. Subsequent childhood allergic disease was assessed by parent report, clinical examination, and repeat skin prick testing.

Results
The covariates of interest varied between NS (n = 698), ST (n = 27), and FA (n = 61) groups as follows, suggesting that across these measures, the ST group was more similar to the NS than the FA group: family history of eczema NS 44.6%, ST. 44.6%, FA 65.6%; pet ownership at 12 months: NS 71.5%, ST 81.5%, FA 45.8%; eczema during the first 12 months: NS 19%, ST 32%, FA 64%; and aeroallergen sensitization at 4 years: NS 19.1%, ST 28.6%, FA 44.4%. At birth, a higher proportion of activated regulatory T cells was associated with ST (OR = 2.89, 95% CI 1.03‐8.16, P = .045).

Conclusion
Food‐sensitized‐tolerance in infancy appears to be associated with a similar pattern of exposures, immunity, and outcomes to nonsensitized infants. In addition, we found some evidence that an elevated proportion of activated regulatory T cells at birth was specific to the sensitized‐tolerant infants, which may be relevant to suppression of clinical disease.

History

Journal

Allergy

Volume

75

Issue

6

Pagination

1404 - 1413

Publisher

Wiley

Location

Chichester, Eng.

ISSN

0105-4538

eISSN

1398-9995

Language

eng

Publication classification

C1 Refereed article in a scholarly journal