Design and development of signal transduction inhibitors for cancer treatment: Experience and challenges with kinase targets

journal contribution

posted on 2024-08-20, 05:50 authored by Ian CollinsIan Collins, Paul Workman

Design and development of signal transduction inhibitors for cancer treatment: Experience and challenges with kinase targets

History

Journal

CURRENT SIGNAL TRANSDUCTION THERAPY

Volume

1

Pagination

13-23

ISSN

1574-3624

eISSN

2212-389X

Language

English

Publication classification

C1.1 Refereed article in a scholarly journal

Issue

1

Publisher

BENTHAM SCIENCE PUBL LTD

Publication URL

http://dx.doi.org/10.2174/157436206775269181

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Keywords

Science & Technology Life Sciences & Biomedicine Pharmacology & Pharmacy cancer kinase inhibitor structure-based design selectivity pharmacodynamics GROWTH-FACTOR RECEPTOR HSP90 MOLECULAR CHAPERONE CYCLIN-DEPENDENT KINASES PROTEIN-KINASE TYROSINE KINASE DRUG DISCOVERY IRREVERSIBLE INHIBITORS ORAL BIOAVAILABILITY LIGAND EFFICIENCY CRYSTAL-STRUCTURE

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