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Design and formulation of twice daily nifedipine sustained release tablet using methocel K15M CR and methocel K100LV CR

journal contribution
posted on 2022-11-30, 05:05 authored by D T Akhter, Riaz UddinRiaz Uddin, N H Huda, K B Sutradhar
The purpose of the present investigation was to design and evaluate sustained release tablets of a poorly water soluble drug nifedipine, employing hydrophilic polymers Methocel K15M CR and Methocel K100LV CR and to select the best formulation based on pharmacokinetic studies. Direct compression method was used to prepare matrix tablets. The granules were evaluated for angle of repose, loose bulk density, tapped bulk density, compressibility index and drug content. The tablets were subjected to various tests for their physical parameters such as thickness, hardness and friability. In vitro release study was carried out for 12 hours using USP paddle type dissolution apparatus in phosphate buffer with sodium lauryl sulphate (pH 6.8). Quantitative evaluation by mathematical model indicates that formulation containing HPMC K15M CR and HPMC K100LV CR in a ratio of 1:3 showed better dissolution properties compared to other formulations. Korsmeyer's plot indicated that the drug release mechanisms from the matrix tablet followed Fickian mechanism. The study indicates that the hydrophilic matrix tablets of nifedipine prepared using Methocel K15M CR and Methocel K100LV CR can successfully be employed as twice-a-day oral controlled release dosage form in order to improve patient compliance.

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Journal

International Journal of Pharmacy and Pharmaceutical Sciences

Volume

4

Pagination

121 - 124

eISSN

0975-1491

Publication classification

C1.1 Refereed article in a scholarly journal

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